| Catalogue number: |
C2574-05D |
| Reactivities: |
Human, Mouse, Rat |
| Hosts: |
Mouse |
| Applications: |
Immunocytochemistry, Immunoprecipitation, Western Blot |
| Size: |
250ul |
| Form: |
Ascitic fluid with 15mM sodium azide |
| P type: |
Mab |
| Isotype: |
IgG2a |
| Purity: |
Ascites |
| Alternative names: |
Cell division protein kinase 4, CMM3, Crk3, Cyclin dependent kinase 4, Melanoma cutaneous malignant 3, MGC14458,cdk4, PSK J3 |
| References: |
Elledge SJ Cell cycle checkpoints: preventing an identity crisis. Science 274:1664-72 (1996). Lukas J et al. Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature 375:503-6 (1995). Lukas J et al. Oncogenic aberrations of p16INK4/CDKN2 and cyclin D1 cooperate to deregulate G1 control. Cancer Res 55:4818-23 (1995). Aagaard L et al. Aberrations of p16Ink4 and retinoblastoma tumour-suppressor genes occur in distinct sub-sets of human cancer cell lines. Int J Cancer 61:115-20 (1995). Motokura T & Arnold A Cyclins and oncogenesis. Biochim Biophys Acta 1155:63-78 (1993). Sherr CJ Mammalian G1 cyclins. Cell 73:1059-65 (1993). Xiong Y et al. Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev 7:1572-83 (1993). Matsushime H et al. Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell 71:323-34 (1992). Freeman RS & Donoghue DJ Protein kinases and protooncogenes: biochemical regulators of the eukaryotic cell cycle. Biochemistry 30:2293-302 (1991). Pines J & Hunter T Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J Cell Biol 115:1-17 (1991). Yamashita M et al. Developmental Growth and Differentiation 33:617 (0). |
| Additional info: |
Reacts specifically with Cdk4. Does not recognize other Cdk types. Species Crossreactivity: Crossreacts with Human, Mouse and Rat. Not yet tested in other species. |
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