CDK4, Recombinant, Human, aa1-303, His-Tag (Cyclin-dependent Kinase 4, CMM3, PSK-J3)

Cyclin-dependent kinase 4, also known as CDK4, belongs to the Cyclin-dependent kinases (CDK) family. CDK are the catalytic subunits of the cyclin/cdk complexes, which phosphorylate substrates on threonine/serine residues. CDK4, in complex with D-type cyclins, is thought to regulate cell growth during the G1 phase of the cell cycle. This association with a D-type cyclin upregulates CDK4 activity, whereas binding to the CDK inhibitor p16 downregulates CDK4 activity. \n\nSource:\nRecombinant protein corresponding to aa1-303 from human CDK4 at N-terminal, fused to His-tag expressed in E.coli. \n\nMolecular Weight: \n~36.1kD (326aa)\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MGS\nHPNVVRLMDV CATSRTDREI KVTLVFEHVD QDLRTYLDKA PPPGLPAETI KDLMRQFLRG LDFLHANCIV HRDLKPENIL VTSGGTVKLA DFGLARIYSY QMALTPVVVT LWYRAPEVLL QSTYATPVDM WSVGCIFAEM FRRKPLFCGN SEADQLGKIF DLIGLPPEDD WPRDVSLPRG MATSRYE PVAEIGVGAY GTVYKARDPH SGHFVALKSV RVPNGGGGGG GLPISTVREV ALLRRLEAFE\nAFPPRGPRPV QSVVPEMEES GAQLLLEMLT FNPHKRISAF RALQHSYLHK DEGNPE\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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