Home  >  Products  >  CDK5 (Cyclin-Dependent Kinase 5, Cell Division Protein Kinase 5, Cyclin-dependent Kinase 5, Serine/Threonine-protein Kinase PSSALRE, Tau Protein Kinase II Catalytic Subunit, TPKII Catalytic Subunit)
CDK5 (Cyclin-Dependent Kinase 5, Cell Division Protein Kinase 5, Cyclin-dependent Kinase 5, Serine/Threonine-protein Kinase PSSALRE, Tau Protein Kinase II Catalytic Subunit, TPKII Catalytic Subunit)

CDK5 (Cyclin-Dependent Kinase 5, Cell Division Protein Kinase 5, Cyclin-dependent Kinase 5, Serine/Threonine-protein Kinase PSSALRE, Tau Protein Kinase II Catalytic Subunit, TPKII Catalytic Subunit)

Cat no: C2575-06C

Supplier: United States Biological
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Cyclin dependent kinase 5 (CdK5) is a member of the cyclin dependent kinase family of serine/threonine kinases. It is present in numerous mammalian tissues including kidney, testes, and ovary. Its activity is detected almost exclusively in brain extracts. Neuronal and muscle cells contain the highest amount of this protein. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, the p35 protein, which is expressed solely in the brain, activates Cdk5. Cdk5 interacts with D1 and D3 type G1 cyclins and can phosphorylate histone H1, TAU, MAP2 and NF-H and NF-M. Cdk5 activity is involved in terminal differentiation of neurons and muscle cells. Applications: Suitable for use in ELISA, Western Blot, and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot:1:1,000-1:2,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2575-06C
Reactivities: Human, Mouse, Rat
Hosts: Mouse
Applications: ELISA, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 50% glycerol.
P type: Mab
Isotype: IgG1,k
Purity: Purified
Additional info: Recognizes human cdk5. Species Cross-Reactivity: mouse, rat.

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