Home  >  Products  >  CDK5 (Cyclin-Dependent Kinase 5, Cell Division Protein Kinase 5, Cyclin-dependent Kinase 5, Serine/Threonine-protein Kinase PSSALRE, Tau Protein Kinase II Catalytic Subunit, TPKII Catalytic Subunit)
CDK5 (Cyclin-Dependent Kinase 5, Cell Division Protein Kinase 5, Cyclin-dependent Kinase 5, Serine/Threonine-protein Kinase PSSALRE, Tau Protein Kinase II Catalytic Subunit, TPKII Catalytic Subunit)

CDK5 (Cyclin-Dependent Kinase 5, Cell Division Protein Kinase 5, Cyclin-dependent Kinase 5, Serine/Threonine-protein Kinase PSSALRE, Tau Protein Kinase II Catalytic Subunit, TPKII Catalytic Subunit)

Cat no: C2575-10B

Supplier: United States Biological
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Cyclin-dependent kinase-5(CDK5) is a member of the cyclin-dependent kinase family of serine/threonine kinases. Its mRNA and protein are expressed in the kidneys, testes, and ovaries. And Its activity has been detected almost exclusively in brain extracts. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity; however, Cdk5 is not activated by cyclins. Instead, Cdk5 activity requires association with one of two brain-specific regulatory subunits, called p35 and p39. These two activators regulate the spatial and temporal expression of active Cdk5, restricting its activity primarily to post-mitotic neurons. FunctionProbably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. Also interacts with p35 which activates the kinase. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Positive Control: SH-SY5Y Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2575-10B
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in HEPES, 0.15M sodium chloride, 0.01% BSA, 0.03% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
References: 1. Shirley B. Shelton and gail V.W. Johnson 2004 Journal of Neurlchemistry 88:1313-1326. 2. Jonathan C Cruz and Li-Huei Tsai 2004 Current Poinion in Neurobiology 14:390-394. 3. Deanna S. Smith, Paul L. Greer, and Li-Huei Tsai 2001 Cell Growth & Differentiation 12:277-283.
Additional info: Recognizes human CDK5. Species Crossreactivity: mouse and rat.

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