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CDK5, NT (Cyclin-dependent Protein Kinase 5, Dr.105878)

CDK5, NT (Cyclin-dependent Protein Kinase 5, Dr.105878)

Cat no: C2575-11A

Supplier: United States Biological
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Regulated progression through the cell cycle requires sequential expression of a family of proteins called cyclins. Upon their induction, cyclins form complexes with specific cyclin-dependent kinases (CDKs), creating active holoenzymes that phosphorylate target proteins required for cell-cycle progression. CDK5 is expressed predominantly in post-mitotic cell populations, and potentially regulates early neuronal development in zebrafish. CDK5 is responsible for regulating neuronal migration, differentiation, axonogenesis, synaptic transmission and apoptosis. Zebrafish CDK5 is 96% identical to the human ortholog. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Optimal dilutions to be determined by the researcher. Control Peptide: C2575-11G Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2575-11A
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.1% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Brown, NR et al (2007) Cell Cycle 6:1350-1359. 2. Kanungo, J et al (2006) J. Neurochem. 99(1):251-259. 3. Kanungo, J et al (2007) Neurosci. Lett. 412(3):233-238.
Additional info: Recognizes zebrafish CDK5.

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