CDK8 Antibody

Cat no: 251215

Supplier: ABBIOTEC

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Description
Additional Information

Cyclin-dependent kinase 8 (CDK8) is a component of the Mediator comple, Xenopus/Amphibian,, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation comple, Xenopus/Amphibian, with RNA polymerase II and the general transcription factors. CDK8 phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation comple, Xenopus/Amphibian,.

Catalogue number:	251215
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P49336
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CDK8.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	CDK8; Cyclin-dependent kinase 8; Cell division protein kinase 8; Mediator of RNA polymerase II transcription subunit CDK8; Mediator comple, Xenopus/Amphibian, subunit CDK8; Protein kinase K35