CDKN3 pAb

Cyclin-dependent kinase inhibitor 3 (CDKN3), also designated Cdk2-associated dual specificity phosphatase, cyclin-dependent kinase interactor 1 (CDI1), CIP2, KAP or KAP1, belongs to the protein-tyrosine phosphatase family. CDKN3, a cyclin-dependent kinase inhibitor, interacts and dephosphorylates Cdk2 kinase, which prevents Cdk2 kinase activation. CDKN3 is important in cell cycle regulation. It is a dual specificity phosphatase that is active toward substrates which contain phosphotyrosine or phosphoserine residues. CDKN3 does not interact with Cdk4, but can interact with other cyclin-dependent kinases such as Cdc2, Cdk2 and Cdk3. The gene encoding for the CDKN3 protein maps to chromosome 14q22. This gene has been noted to be mutated, overexpressed or deleted in many cancers. Defects in the CDKN3 gene may may be implicated in hepatocellular carcinoma (HCC).

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SPECIFICATIONS

Catalog Number

BS6562

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human CDKN3.

Species

CDKN3 pAb detects endogenous levels of CDKN3 protein.

Dilutions

WB: 1:500~1:2000\nIHC: 1:50~1:200

Swiss Prot

Q16667

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul