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CDKN3 pAb

CDKN3 pAb

Cat no: BS6562

Supplier: Bioworld Technology, Inc.
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Cyclin-dependent kinase inhibitor 3 (CDKN3), also designated Cdk2-associated dual specificity phosphatase, cyclin-dependent kinase interactor 1 (CDI1), CIP2, KAP or KAP1, belongs to the protein-tyrosine phosphatase family. CDKN3, a cyclin-dependent kinase inhibitor, interacts and dephosphorylates Cdk2 kinase, which prevents Cdk2 kinase activation. CDKN3 is important in cell cycle regulation. It is a dual specificity phosphatase that is active toward substrates which contain phosphotyrosine or phosphoserine residues. CDKN3 does not interact with Cdk4, but can interact with other cyclin-dependent kinases such as Cdc2, Cdk2 and Cdk3. The gene encoding for the CDKN3 protein maps to chromosome 14q22. This gene has been noted to be mutated, overexpressed or deleted in many cancers. Defects in the CDKN3 gene may may be implicated in hepatocellular carcinoma (HCC).
Catalogue number: BS6562
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: Q16667
Dilutions: WB: 1:500~1:2000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Recombinant full length Human CDKN3.
Species: CDKN3 pAb detects endogenous levels of CDKN3 protein.
Molecular weight: ~ 24 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Cyclin-dependent kinase inhibitor 3; CDI1; CIP2; KAP; CDKN3;
Additional info: For research use only, not for use in diagnostic procedure.

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