Signaling lymphocytic activation molecule (SLAM, SLAMF1; CD150) was the first identified of
a family of type I transmembrane (TM) lymphocyte activating receptors. SLAM homotypic
adhesion bidirectionally stimulates T and B cells. SLAM is also expressed by hematopoietic
stem cells, dendritic cells and platelets and is a T cell measles virus receptor. The 70kD
glycoprotein contains a 216aa extracellular domain (ECD) with one C2 type and one V type Ig-like domain, a 20aa TM sequence and a 76aa SH2-binding cytoplasmic domain. One splice variant has a shorter cytoplasmic tail and another lacks the TM sequence and is secreted. Human and mouse SLAM ECD share 60% aa identity.
Applications:
Suitable for use in Flow Cytometry and Western Blot. Other applications not tested.
Recommended Dilution:
Western Blot: 2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile 40-50% glycerol, PBS.. Aliquot and store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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