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CDX2 (CDX2, Caudal Type Homeobox Transcription Factor 2, HGNC:1806, CDX-3, CDX3)

CDX2 (CDX2, Caudal Type Homeobox Transcription Factor 2, HGNC:1806, CDX-3, CDX3)

Cat no: C2589-57

Supplier: United States Biological
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CDX2 is a caudal type homeobox gene that encodes an intestine-specific transcription factor that is expressed early in intestinal development and may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. It is expressed in the nuclei of epithelial cells throughout the intestine, from duodenum to rectum. The CDX2 protein is expressed in primary and metastatic colorectal carcinomas and has also been demonstrated in the intestinal metaplasia of the stomach and intestinal-type gastric cancer, while it is not expressed in the normal gastric mucosa. Studies have shown that CDX2 is superior marker compared to CK20. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Paraffin): 1:25-1:50. ABC method; incubation period of 60 min at RT. FFPE tissue sections require high temperature antigen unmasking with 1mM EDTA buffer, pH 8.0 prior to immunostaining. Immunohistochemistry: 1:10-1:2000 Optimal dilutions to be determined by the researcher. Recommended Positive Control: Colon cancer Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2589-57
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Tissue culture supernatant
Alternative names: CDX2, Caudal Type Homeobox Transcription Factor 2, HGNC:1806, CDX-3, CDX3
References: 11. Bai YQ et al. Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. Cancer Lett 176:47-55 (2002). 2. Hinoi T et al. Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon. Am J Pathol 159:2239-48 (2001). 3. Silberg DG et al. Cdx1 and cdx2 expression during intestinal development. Gastroenterology 119:961-71 (2000).
Additional info: Recognizes human CDX2.

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