The caudal-related homeodomain protein 2, CDX-2, is a transcription factor which is expressed in the intestine and is thought to play an important role in the proliferation and differentiation of intestinal epithelial cells. The CDX-2 protein is expressed in primary and metastatic colorectal carcinomas, intestinal metaplasia of the stomach and intestinal type gastric cancer. In human colorectal cancer, the expression of both CDX2 and carbonic anhydrase 1, a gene regulated by CDX2, is reduced or absent (1). CDX-2 is one of the important regulators in defining pathways for coordinate control of drug metabolism in the gastrointestinal tract (2).
Applications:
Suitable for use in Flow Cytometry, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended Dilution:
Western Blot: 1:1000-1:5000
Immunohistochemistry: 1:250-1:500
Immunocytochemistry: 1:100-1:250
Flow Cytometry: 1:40
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
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