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CDX2 (Homeobox Protein CDX-2, CDX-3, Caudal-type Homeobox Protein 2, CDX3)

CDX2 (Homeobox Protein CDX-2, CDX-3, Caudal-type Homeobox Protein 2, CDX3)

Cat no: C2589-57A

Supplier: United States Biological
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CDX2 is a caudal-type homeobox domain-containing transcription factor, important in the development and differentiation of the intestines.It is a part of a regulatory network that orchestrates a developmental program of proliferation, morphogenesis, and gene expression in the intestinal epithelium. It has 311aa and its homeodomain is a 60-aamotif containing a sequence-specific DNA binding domain. The human CDX2 gene is localized to chromosome 13q12-13. The protein has been shown to positively regulate genes expressed in the small intestine such as sucraseisomaltase, lactase and phospholipase A. CDX2 has been implicated in disorders involving abnormal intestinal differentiation and neoplasia. It is also a sensitive and specific marker for colorectal adenocarcinoma, although its expression is decreased among higher grade and stage tumors, and it is not invariably present in metastases from positive primaries. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (formalin fixed paraffin embedded): 1:25-1:50 Optimal dilutions to be determined by the researcher. Positive Control: Colon cancer Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2589-57A
Reactivities: Human, Mouse
Hosts: Mouse
Applications: Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Supernatant
References: 1. Bai et al. Cancer Letter 176: 47, 2002 2. Hinoi et al. Am J Pathol 159: 2239, 2001 3. Silberg et al. Gastroenterology 119: 961, 2000 4. Sivagnanasundaram et al. British Journal of Cancer 84: 218, 2001. 5. Drummond et al. Ann Hum Genet 61: 393, 1997. 6. Vassil et al. Modern Pathology 17: 1392, 2004.
Additional info: Recognizes human CDX2. Species Crossreactivity: mouse.

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