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CDX2 (Homeobox Protein CDX-2, CDX-3, Caudal-type Homeobox Protein 2, CDX3)

CDX2 (Homeobox Protein CDX-2, CDX-3, Caudal-type Homeobox Protein 2, CDX3)

Cat no: C2589-57C

Supplier: United States Biological
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CDX2 is a homeobox protein that binds to the A/T rich sequence in the insulin promoter to stimulate transcription. It is a caudal type homeobox gene that encodes an intestine-specific transcription factor that is expressed early in intestinal development. The CDX2 protein is expressed in primary and metastatic colorectal carcinomas and has also been demonstrated in the intestinal metaplasia of the stomach and intestinal-type gastric cancer. It also plays an important role in maintenance of epithelial lining of the intestines. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher. Positive Control: HCT-116 cells (human colon carcinoma) Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2589-57C
Reactivities: Human, Mouse, Rat, Bovine
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Alkhoury, S. et al. Am. J. Physiol. Gastrointest. Liver Physiol. 289:G285-G290 (2005). 2. Chase, A. et al. Blood 93:1025-1031 (1999). 3. Kazumori, H. et al. Gut. 58:620-628 (2009).
Additional info: Recognizes human CDX2. Species Crossreactivity: bovine, equine, mouse, opossum, rat, rhesus monkey. Species sequence homology: chicken.

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