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CEBP alpha (CCAAT Enhancer Binding Protein, alpha)

CEBP alpha (CCAAT Enhancer Binding Protein, alpha)

Cat no: C2589-91

Supplier: United States Biological
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The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. Mutations in this gene are frequently found in acute myeloid leukemia (AML). Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Western Blot: 2 ug/ml detects a band at ~45kD. Optimal dilutions to be determined by the researcher. Positive Control: Transfected hu293T cells. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2589-91
Reactivities: Human, Mouse, Rat
Hosts: Mouse
Applications: Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 1mg/ml BSA, 0.05% sodium azide.
P type: Mab
Isotype: IgG
Purity: Purified
References: 1. Ferrari-Amorotti, G., Keeshan, K., Zattoni, M., Guerzoni, C., Iotti, G., Cattelani, S., Donato, N. J., and Calabretta, B. (2006) Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBP{alpha}. Blood. 108:1353-1362.
Additional info: Recognizes mouse CEBP alpha. Species Crossreactivity: human and rat. Species Sequence Homology: Xenopus laevis, hamster; 100%, zebrafish, goldfish, S. pombe; 92%, Aspergillus nidulans, Neurospora crassa; 85%.

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