Cells, PBMC, Dendritic Cells, BioPrimary(TM)

BioPrimary(TM) Cells are derived using technology including advanced protocols and adjuvants that ehance the viability of our cells to over >90% total post-thaw viability.\n\nDendritic cells (DCs) are immune cells that form part of the mammalian immune system. Their main function is to process antigen material and present it on the surface to other cells of the immune system, thus functioning as antigen-presenting cells. They act as messengers between the innate and adaptive immunity.\n\nDendritic cells are present in small quantities in tissues that are in contact with the external environment, mainly the skin and the inner lining of the nose, lungs, stomach and intestines. They can also be found in an immature state in the blood. Once activated, they migrate to the lymphoid node where they interact with T cells and B cells to initiate and shape the adaptive immune response.\n\nRole in HIV, Allergy, and Autoimmune Diseases:\nHIV, which causes AIDS, can bind to dendritic cells via various receptors expressed on the cell. The best studied example is DC-SIGN (usually on MDC subset 1, but also on other subsets under certain conditions; since not all dendritic cell subsets express DC-SIGN, its exact role in sexual HIV-1 transmission is not clear). When the dendritic cell takes up HIV and then travels to the lymph node, the virus is able to move to helper T-cells, and this infection of helper T-cells is the major cause of disease. Altered function of dendritic cells is also known to play a major or even key role in allergy and autoimmune diseases like lupus erythematosus and inflammatory bowel diseases (Crohn's diseaseand ulcerative colitis).\n\nAll products are shipped on dry ice with: 1) Certificate of Analysis (with viability and purity results), and 2) Thawing instructions\n\nStorage and Stability: \nIt is recommended that cells are used as soon as possible following receipt to ensure optimal viability. Cells may be stored at -80 C for up to one month (minimize storage length at -80 C in order to maximize viability).\n

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