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CENP-Q (Centromere Protein Q)

CENP-Q (Centromere Protein Q)

Cat no: C2615-25

Supplier: United States Biological
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Cenp-Q (also known as centromere protein Q or CENPQ) is a nuclear/centromeric protein that is one of the critical components that constitutes the CENP-O complex at the kinetochores and appears to stabilize PBIP1/CENP-U(50)/MLF1IP in the complex. This complex is important for proper recruitment of polo-like kinase 1 (Plk1) to the mitotic kinetochores. A failure in this process results in improper microtubule attachment to the kinetochores and chromosome missegregation that ultimately lead to aneuploidy. Applications: Suitable for use in Immunofluorescence, ELISA and Western Blot. Other applications not tested. Recommended Dilution: Immunofluorescence: 1:100-1:500 ELISA: 1:20,000
Catalogue number: C2615-25
Hosts: Rabbit
Applications: ELISA, Immunofluorescence, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1.Hori T, Okada M, Maenaka K, Fukagawa T. (2008) CENP-O Class Proteins Form a Stable Complex and Are Required for Proper Kinetochore Function. Mol Biol Cell. Mar;19(3):843-54. Epub 2007 Dec 19. 2.Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T. (2006) The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. Nat Cell Biol. May;8(5):446-57. Epub 2006 Apr 16. 3.Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW. (2006) The human CENP-A centromeric nucleosome-associated complex. Nat Cell Biol. May;8(5):458-69. Epub 2006 Apr 16. with bisbenzimide. Personal Communication, Kyung S. Lee, CCR-NCI, Bethesda, MD.
Additional info: Species Sequence Homology: macaque(91%), horse(76%), bovine(74%), dog(73%), swine (71%), mouse(65%) and rat(60%).

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