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Ceratotoxin-2

Cat no: STC-100

Ceratotoxin-2

Ceratotoxin-2. A potent blocker of central nervous system voltage-gated Na+ channel.

Ceratotoxin-2 was originally isolated from the Ceratogyrus cornuatus (Ceratogyrus marshalli, Staighthorned baboon tarantula) venom.
Ceratotoxin-2 modulates different voltage-gated Na+ channel subtypes from the central nervous system (Nav1.1-Nav1.5 and Nav1.8) by shifting the voltage dependence of channel activation to more depolarized potentials and by blocking the inward component of the Na+ current. It is significantly more potent against Nav1.2 channel than the other Nav channel subtypes.

Ion Channel Modulators; Voltage - Gated Na+ Channel Blockers

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SPECIFICATIONS

Catalog Number

STC-100

Size

50 micro g

Purity

>98%

Concentration

5 nM - 2 micro M

Shipping Temp

Room Temperature

Molecular Weight

4093 Da

SUPPLIER INFO

Alomone Labs Ltd.

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