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Cerebellin-1, CT (Cerebellin 1, CBLN1, Cerebellin 1 Precursor, Precerebellin)

Cerebellin-1, CT (Cerebellin 1, CBLN1, Cerebellin 1 Precursor, Precerebellin)

Cat no: C2790-55

Supplier: United States Biological
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Precerebellin is required for synapse integrity and synaptic plasticity and for the ER export and secretion of CBLN3. Precerebellin exerts neuromodulatory functions including directly stimulating norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release. Research indicates that Precerebellin may also be involved in a wider range of functions than have been so far demonstrated. Applications: Suitable for use in Immunohistochemistry (frozen) and Western Blot. Other applications not tested. Recommended Dilution: immunohistochemistry (frozen): 10ug/ml Western Blot: 2-4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2790-55
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Albertin G., et al (2000) Cerebellin stimulates the secretory activity of the rat adrenal gland: in vitro and in vivo studies. Neuropeptides 34:7-11 2. Mazzocchi G., et al (1999) Cerebellin enhances in vitro secretory activity of human adrenal gland. J. Clin. Endocrinol. Metab. 84:632-5. 3. Urade Y., et al (1991) Precerebellin is a cerebellum-specific protein with similarity to the globular component C1q B chain. PNAS 88:1069-73.
Additional info: Recognizes human CBLN1. Species Crossreactivity: mouse and rat.

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