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Cerebellin Precursor, CT (CBLN1, Precerebellin, Cerebellin-1)

Cerebellin Precursor, CT (CBLN1, Precerebellin, Cerebellin-1)

Cat no: C2790-50F

Supplier: United States Biological
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Precerebellin is the precursor of the brain-specific hexadecapeptide cerebellin, a protein with substantial similarity to the globular region of the B chain of complement component C1q. Cerebellin exerts neuromodulatory functions by directly stimulating norepinephrine release via the adenylate cyclase/pka- dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release. The active form of precerebellin is highly enriched in postsynaptic structures of cerebellar Purkinje cells in cartwheel neurons of the dorsal cochlear nucleus. Because precerebellin belongs to the C1q/tumor necrosis factor superfamily of secreted proteins and has similarity to adiponectin and CTRP3, it has been suggested that precerebellin posseses functions other than those already stated. Applications: Suitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 2-4ug/ml Optimal dilutions to be determined by the researcher. Positive Control: 293 cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2790-50F
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Immunocytochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified
References: 1. Urade Y, et al (1991) Proc. Natl. Acad. Sci. USA. 88:1069-73. 2. Mazzocchi G, et al (1999) J. Clin. Endocrinol. Metab. 84:632-5. 3. Albertin G, et al (2000) Neuropeptides. 34:7-11. 4. Shamji AF, et al (1985) Proc. Natl. Acad. Sci. USA. 82:7145-8. 5. Bao D, et al (2005) J. Neurochem. 94:618-29.
Additional info: Recognizes human precerebellin. Species Crossreactivity: mouse and rat.

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