Home  >  Products  >  CES1 (Carboxylesterase 1, ACAT, CEH, Monocyte/macrophage serine esterase 1, HMSE, HMSE1, MGC117365, PCE-1, SES1, TGH, acyl coenzyme A:cholesterol acyltransferase, carboxylesterase 1, carboxylesterase 2 (liver), cholesteryl ester hydrolase, egasyn)
CES1 (Carboxylesterase 1, ACAT, CEH, Monocyte/macrophage serine esterase 1, HMSE, HMSE1, MGC117365, PCE-1, SES1, TGH, acyl coenzyme A:cholesterol acyltransferase, carboxylesterase 1, carboxylesterase 2 (liver), cholesteryl ester hydrolase, egasyn)

CES1 (Carboxylesterase 1, ACAT, CEH, Monocyte/macrophage serine esterase 1, HMSE, HMSE1, MGC117365, PCE-1, SES1, TGH, acyl coenzyme A:cholesterol acyltransferase, carboxylesterase 1, carboxylesterase 2 (liver), cholesteryl ester hydrolase, egasyn)

Cat no: C3010-02A

Supplier: United States Biological
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Carboxylesterases (CES) are ubiquitous enzymes responsible for the hydrolysis of endogenous substrates with ester, thioester, or amide bonds and of xenobiotics (effecting detoxification or drug metabolism). Drug half-life and bioavailability may be modulated by selective inhibition of these proteins. CES1 or hCE1 (also known as acyl coenzyme A:cholesterol acyltransferase, monocyte/macrophage serine esterase, HMSE, serine esterase 1, brain carboxylesterase, triacylglycerol hydrolase, egasyn and retinyl ester hydrolase) is responsible for hydrolysis of stored cholesterol esters in macrophage foam cells and release of free cholesterol for high density lipoprotein-mediated cholesterol efflux. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:2,500
Catalogue number: C3010-02A
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 100ul
Form: Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1.Bushman F. (2003) Targeting Survival Integration Site Selection by Retroviruses and LTR-Retrotransposons. Cell 115: 135-138. 2.Danks MK, Morton CL, Krull EJ, Cheshire PJ, Richmond LB, Naeve CW, Pawlik CA, Houghton PJ, and Potter PM. Comparison of Activation of CPT-11 by Rabbit and Human Carboxylesterases for Use in Enzyme/Prodrug Therapy Clin. Cancer Res., 5:917-924, 1999. 3.Bencharit S, Morton CL, Xue Y, Potter PM, Redinbo MR. (2003) Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme. Nat Struct Biol 10:349-356 4.Ghosh S, Natarajan R. (2001). Cloning of the human cholesteryl ester hydrolase promoter: identification of functional peroxisomal proliferator-activated receptor responsive elements. Biochem. Biophys. Res. Commun. 284: 1065-1070, 2001.

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