CETN3 (Centrin-3, CEN3)

CETN3 contains four EF-hand calcium binding domains, and is a member of the centrin protein family. This protein is ubiquitously expressed cytoskeletal components that show increased expression during cell differentiation. It plays a role in centrosome reproduction.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nAA Sequence:\nMSLALRSELVVDKTKRKKRRELSEEQKQEIKDAFELFDTDKDEAIDYHELKVAMRALGFDVKKADVLKILKDYDREATGKITFEDFNEVVTDWILERDPH\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

124890

Size

100ug

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG2b,k

References

1. DNA damage-induced centrosome amplification occurs via excessive formation of centriolar satellites. Loffler H, Fechter A, Liu FY, Poppelreuther S, Kramer A.Oncogene. 2012 Jul 23. doi: 10.1038/onc.2012.310. 2. A primary microcephaly protein complex forms a ring around parental centrioles. Sir JH, Barr AR, Nicholas AK, Carvalho OP, Khurshid M, Sossick A, Reichelt S, D'Santos C, Woods CG, Gergely F.Nat Genet. 2011 Oct 9;43(11):1147-53. doi: 10.1038/ng.971. 3. Defective nucleotide excision repair with normal centrosome structures and functions in the absence of all vertebrate centrins. Dantas TJ, Wang Y, Lalor P, Dockery P, Morrison CG.J Cell Biol. 2011 Apr 11. [Epub ahead of print] 4. TPCK targets elements of mitotic spindle and induces cell cycle arrest in prometaphase. Fabian Z, Fearnhead HO.Biochem Biophys Res Commun. 2010 Apr 8. [Epub ahead of print] 5. CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response. Barr AR, Kilmartin JV, Gergely F.J Cell Biol. 2010 Apr 5;189(1):23-39.

Additional Info

Recognizes human CETN3.