CFL2, Recombinant, Human, aa1-166, His-tag (Cofilin-2, Cofilin, Muscle Isoform)

Cat no: C7506-52

Supplier: United States Biological

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CFL2 belongs to the actin-binding proteins ADF family that contains 1 ADF-H domain. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. Defects in CFL2 are the cause of nemaline myopathy type 7 (NEM7). Source: Recombinant corresponding to aa1-166 from human CFL2, fused to His-tag at N-terminal expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASGVTVNDE VIKVFNDMKV RKSSTQEEIK KRKKAVLFCL SDDKRQIIVE EAKQILVGDI GDTVEDPYTS FVKLLPLNDC RYALYDATYE TKESKKEDLV FIFWAPESAP LKSKMIYASS KDAIKKKFTG IKHEWQVNGL DDIKDRSTLG EKLGGNVVVS LEGKPL Molecular Weight: ~20.9kD (MALDI-TOF) Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Catalogue number:	C7506-52
Size:	100ug
Form:	Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 2mM DTT, 10% glycerol, 50mM sodium chloride.
Purity:	~90% (SDS-PAGE)
References:	1. Agrawal P.B., et al. (2007) Am. J. Hum. Genet. 80:162-167. 2. Gillett GT, et al. (1996). Ann. Hum. Genet. 60 (Pt3): 201-11.

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CFL2, Recombinant, Human, aa1-166, His-tag (Cofilin-2, Cofilin, Muscle Isoform)

Cat no: C7506-52

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