Home  >  Products  >  CGBP (CpG-binding Protein, CXXC-type Zinc Finger Protein 1, PHD Finger and CXXC Domain-containing Protein 1, CXXC1, CFP1, PCCX1, PHF18)
CGBP (CpG-binding Protein, CXXC-type Zinc Finger Protein 1, PHD Finger and CXXC Domain-containing Protein 1, CXXC1, CFP1, PCCX1, PHF18)

CGBP (CpG-binding Protein, CXXC-type Zinc Finger Protein 1, PHD Finger and CXXC Domain-containing Protein 1, CXXC1, CFP1, PCCX1, PHF18)

Cat no: C3375-01

Supplier: United States Biological
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Human CpG binding protein (hCGBP) contains three cysteine-rich domains, two of which exhibit homology to the plant homeodomain finger domain and the third cysteine-rich domain conforms to the CXXC motif identified in DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1. A fragment of hCGBP that contains the CXXC domain binds to an oligonucleotide probe containing a single CpG site, and this complex is disrupted by distinct oligonucleotide competitors that also contain a CpG motif(s). CBGP plays an important part in embryonic viability and peri-implantation development. Native hCGBP is detected as an 88kD protein by Western analysis and is ubiquitously expressed. CGBP trans-activates promoters that contain CpG motifs but not promoters in which the CpG is ablated suggesting that hCGBP is a transcriptional activator that recognizes unmethylated CpG dinucleotides. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Positive Control: Human spleen Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C3375-01
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 200ul
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity Chromatography.
References: 1. Voo KS, Carlone DL, Jacobsen BM, Flodin A, and Skalnik DG. Mol Cell Biol, 20 (6): 2108-2121 (2000). 2. Carlone DL, Skalnik DG. Mol Cell Biol 21(22):7601-7606 (2001). 3. Lee JH, Skalnik DG. J Biol Chem 2002 Aug 27; [epub ahead of print].
Additional info: Recognizes human CGBP.

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