Home  >  Products  >  cGMP Binding cGMP-Specific Phosphodiesterase V (PDE5, PDE5A, CN5A, PDE5,CGB-PDE, phosphodiesterase 5A, cGMP-specific, cGMP-binding cGMP-specific 3', 5'-cyclic nucleotide phosphodiesterase)
cGMP Binding cGMP-Specific Phosphodiesterase V (PDE5, PDE5A, CN5A, PDE5,CGB-PDE, phosphodiesterase 5A, cGMP-specific, cGMP-binding cGMP-specific 3', 5'-cyclic nucleotide phosphodiesterase)

cGMP Binding cGMP-Specific Phosphodiesterase V (PDE5, PDE5A, CN5A, PDE5,CGB-PDE, phosphodiesterase 5A, cGMP-specific, cGMP-binding cGMP-specific 3', 5'-cyclic nucleotide phosphodiesterase)

Cat no: C3400-01A

Supplier: United States Biological
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This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C3400-01A
Reactivities: Human, Rat, Canine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris-saline, pH 7.2. 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: PDE5, PDE5A, CN5A, PDE5,CGB-PDE, phosphodiesterase 5A, cGMP-specific, cGMP-binding cGMP-specific 3', 5'-cyclic nucleotide phosphodiesterase
References: Morelli A, Filippi S, Mancina R, Luconi M, Vignozzi L, Marini M, Orlando C, Vannelli GB, Aversa A, Natali A, Forti G, Giorgi M, Jannini EA, Ledda F, Maggi M. Androgens regulate phosphodiesterase type 5 expression and functional activity in corpora cavernosa. Endocrinology. 2004 May;145(5):2253-63. Epub 2004 Feb 05. PMID: 14764637
Additional info: Recognizes human PDE5A. Species Crossreactivity: rat and canine.

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