Home  >  Products  >  Chapsyn 110 (PSD93, Discs Large Homolog 2, DLG2, Channel-associated Protein of SynapsesChapsyn 110 (PSD93, Discs Large Homolog 2, DLG2, Channel-associated Protein of Synapses)
Chapsyn 110 (PSD93, Discs Large Homolog 2, DLG2, Channel-associated Protein of SynapsesChapsyn 110 (PSD93, Discs Large Homolog 2, DLG2, Channel-associated Protein of Synapses)

Chapsyn 110 (PSD93, Discs Large Homolog 2, DLG2, Channel-associated Protein of SynapsesChapsyn 110 (PSD93, Discs Large Homolog 2, DLG2, Channel-associated Protein of Synapses)

Cat no: C3550-05

Supplier: United States Biological
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Chapsyn-110, is a part of the membrane-associated putative guanylate kinase (MAGUK) family. It binds directly to the NMDA receptor, and Shaker K+ channel subunits, and is 70-80% identical to PSD-95/SAP90 and SAP97 (1). It associated tightly with the postsynaptic density I brain, and mediates the clustering of both NMDA recpetors and K+ channels in heterologous cells. The encoded protein forms a heterodimer with PSD-95 that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins (1, 2). Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot:1-10ug/ml Immunohistochemistry:0.1-1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C3550-05
Reactivities: Human, Mouse, Rat
Hosts: Mouse
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH7.4, 50% glycerol and 0.09% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Kim E., et al. (1996) Neuron.17:103-113. 2. Godreau D., Neyroud N., Vranckx R. and Hatem S. (2004) Med Sci (Paris). 20(1):84-88.
Additional info: Recognizes rat Chapsyn-110. Species Crossreactivity: human (weak). No cross-reactivity against other.

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