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Chek2, CT (Novel Protein Similar to Vertebrate CHK2 Checkpoint Homolog (S. pombe) (CHEK2, zgc:55865), CH211-207K7.3, Dr.76006, CH211-207K7.3-001, Chek-2)

Cat no: C4201-06M

Chek2, CT (Novel Protein Similar to Vertebrate CHK2 Checkpoint Homolog (S. pombe) (CHEK2, zgc:55865), CH211-207K7.3, Dr.76006, CH211-207K7.3-001, Chek-2)

Checkpoint kinase 2 (Chek2) is emerging as a key mediator of diverse cellular responses to genotoxic stress, guarding the integrity of the genome throughout eukaryotic evolution. Recent studies show the fundamental role of Chek2 in the network of genome-surveillance pathways that coordinate cell-cycle progression with DNA repair and cell survival or death. Defects in Chek2 contribute to the development of both hereditary and sporadic human cancers, and earmark this kinase as a candidate tumor suppressor and an attractive target for drug discovery.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:5000-1:20,000\nWestern Blot: 1:500-1:1000\nOptimal dilutions to be determined by the researcher.\n\nControl Peptide: C4201-06Q\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C4201-06M

Size

250ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

ZF/Fish

Form

Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Bartek J, et al. Nat Rev Mol Cell Biol. Dec;2(12):877-86 (2001). 2. Elledge, S. J. Science 274, 1664

Additional Info

Recognizes zebrafish Chek2.

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