Chemokine (C-C motif) ligand 22 (CCL22, A-152E5.1, ABCD-1, CC chemokine STCP-1, C-C motif chemokine 22, DC/B-CK, Macrophage-derived chemokine, MDC, MDC(1-69), MGC34554, SCYA22, Small-inducible cytokine A22, STCP-1, Stimulated T-cell chemotactic protein 1)

Chemokines are a large family of small secreted proteins that regulate migration of white blood cells. Based on the arrangement of the first two of the four conserved cysteine residues, chemokines are classified into four subfamilies, CXC, CC, C and recently identified CX3C \n(1). The CC chemokines, in which the first 2 cysteines are adjacent, usually act on monocytes, T lymphocytes, and, in some cases, eosinophils, basophils, or mast cells. The CC subfamily proteins are 70 to 100 amino acids long, have 25 to 75% identity with each other, and include novel member of the CC chemokine subfamily, designated ABCD1 (SCYA22). The SCYA22 protein shares 28 to 34% identity with other CC chemokines and contains the characteristic 4-cysteine motif and 9 other highly conserved residues (2). The activated T cell-attracting CC chemokine CCL22 is expressed by stimulated B cells and mature dendritic cells (DC). Both \nidentical and distinct proteins contribute to expression of CCL22 in DC and B cells (3). \n \nApplications: \nSuitable for use in Western Blot. Other applications not tested. \n\nRecommended Dilutions: \nWestern Blot: 1:250-500 \nOptimal dilution determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. \n\nManufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.

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SPECIFICATIONS

Catalog Number

C0006-11

Size

100ul

Applications

WB

Hosts

Rabbit

Reactivities

Mouse

Form

Supplied as a liquid in 50 mM Tris-Glycine (pH 7.4), 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

P Type

Mab

Purity

Serum

References

1. Nomiyama H, et al. Cytogenetics and Cell Genetics 81 :10-11, 1998. 2. Godiska R, et al. J Exp Med 185(9): 1595-604, 1997. 3. Ghadially H, et al. J Immunol 174(9): 5620-9, 2005.

Additional Info

Recognizes mouse ABCD-1.