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CHIR-99021

Cat no: 006005

CHIR-99021

CHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3). CHIR-99021 activates glycogen synthesis in CHO-IR cells and in isolated type 1 diabetic rat skeletal muscle. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells.\n\nAtmoshpere: \nInert gas\n\nMelting Point:\nAs Reported\n\nSolubility:\nAs Reported\n\nStability:\nAs Reported\n\nMethod for Determining Identity: Proton NMR (DMSO-d6, CD3OD) Spectroscopic and Mass Spectrometric Analysis\n\nTLC Conditions:\nAs Reported\n\nChloride Content:\nAs Reported\n\nElemental Analysis:\nAs Reported\n\nStorage and Stability:\nMay be stored at RT for short-term only. Long-term storage is recommended at 4 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.\n\nToxicity and Hazards:\nAll products should be handled by qualified personnel only, trained in laboratory procedures.\n

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SPECIFICATIONS

Catalog Number

006005

Size

10mg

Form

As Reported

Purity

~90%

References

Ring, et al.: Diabetes, 52, 588 (2003); Tighe, et al.: Cell Biol., 8, 34 (2007); Pan, et al.: Neuropsychopharmacology, 36, 1397 (2011);

Alternative Names

6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile; CHIR 911; CT 99021;

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SUPPLIER INFO

United States Biological

Applications

ELISA

Reactivities

Hum

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Applications

IF

Hosts

Mouse

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Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

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Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

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Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info
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