CHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3). CHIR-99021 activates glycogen synthesis in CHO-IR cells and in isolated type 1 diabetic rat skeletal muscle. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells.
Atmoshpere:
Inert gas
Melting Point:
As Reported
Solubility:
As Reported
Stability:
As Reported
Method for Determining Identity: Proton NMR (DMSO-d6, CD3OD) Spectroscopic and Mass Spectrometric Analysis
TLC Conditions:
As Reported
Chloride Content:
As Reported
Elemental Analysis:
As Reported
Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at 4 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Toxicity and Hazards:
All products should be handled by qualified personnel only, trained in laboratory procedures.