CHIR-99021

Cat no: 006005

Supplier: United States Biological

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CHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3). CHIR-99021 activates glycogen synthesis in CHO-IR cells and in isolated type 1 diabetic rat skeletal muscle. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells. Atmoshpere: Inert gas Melting Point: As Reported Solubility: As Reported Stability: As Reported Method for Determining Identity: Proton NMR (DMSO-d6, CD3OD) Spectroscopic and Mass Spectrometric Analysis TLC Conditions: As Reported Chloride Content: As Reported Elemental Analysis: As Reported Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.

Catalogue number:	006005
Size:	10mg
Form:	As Reported
Purity:	~90%
Alternative names:	6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile; CHIR 911; CT 99021;
References:	Ring, et al.: Diabetes, 52, 588 (2003); Tighe, et al.: Cell Biol., 8, 34 (2007); Pan, et al.: Neuropsychopharmacology, 36, 1397 (2011);

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CHIR-99021

Cat no: 006005

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