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CHK1 (2G1D) Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 252622

CHK1 (2G1D) Antibody

CHK1 (Serine/threonine-protein kinase CHK1) is required for checkpoint-medated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. CHK1 phosphorylates Cdc25, an important phosphatase in cell cycle control,Porcinearticularly for entry into mitosis. Cdc25, when phosphorylated on serine 216 by Chk1 becomes bound by an adaptor protein in the cytoplasm. Therefore it is inhibited from removing the inhibiting phosphate from MPF (mitotic/maturation promoting factor) added by Wee1. Consequently, a cell is prevented from entering mitosis. Chk1 can also phosphorylate p53 at Ser20 in vitro.

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SPECIFICATIONS

Catalog Number

252622

Size

0.1 mg

Applications

WB

Reactivities

Hum, Mouse

Format

Each vial contains 0.1 mg IgG in PBS pH7.4 with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Mouse Monoclonal Antibody

Antigen

Purified recombinant fragment of CHK1 e, Xenopus/Amphibian,pressed in E. coli.

Isotype

Mouse IgG1

Accession

O14757

Clonality

2G1D5

Additional Info

CHEK1; CHK1; Serine/threonine-protein kinase Chk1; CHK1 checkpoint homolog; Cell cycle checkpoint kinase; Checkpoint kinase-1

SUPPLIER INFO

ABBIOTEC

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