Home  >  Products  >  Chk1, phosphorylated (Ser317) (CHEK1, Cell Cycle Checkpoint Kinase, Serine/threonine protein kinase Chk1)
Chk1, phosphorylated (Ser317) (CHEK1, Cell Cycle Checkpoint Kinase, Serine/threonine protein kinase Chk1)

Chk1, phosphorylated (Ser317) (CHEK1, Cell Cycle Checkpoint Kinase, Serine/threonine protein kinase Chk1)

Cat no: C4200-04P

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
Chk1 is a 58kD protein kinase, which acts as an important initiator at the G2 checkpoint during cell cycle arrest, in response to DNA damage. Studies have shown that Chk1 is a downstream target of ATM (ataxia-telangiectasia-mutated) protein kinase, a key component of the DNA damage checkpoint, and that ATR (the ATM- and Rad3-related) protein kinase phosphorylates Ser317 and Ser345 residues within Chk1, activating its kinase activity. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:5,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C4200-04P
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in tris-citrate/phosphate, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: CHK1 Checkpoint Homolog (S. pombe)
References: Chk1 is a 58kDa protein kinase, which acts as an important initiator at the G2 checkpoint during cell cycle arrest, in response to DNA damage. Studies have shown that Chk1 is a downstream target of ATM (ataxia-telangiectasia-mutated) protein kinase, a key component of the DNA damage checkpoint, and that ATR (the ATM- and Rad3-related) protein kinase phosphorylates Ser317 and Ser345 residues within Chk1, activating its kinase activity.
Additional info: Recognizes human Chk1 (cell cycle checkpoint kinase homolog 1) when phosphorylated at Ser317.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave