Home  >  Products  >  CHK2 (1C12) Antibody
CHK2 (1C12) Antibody

CHK2 (1C12) Antibody

Cat no: 252785

Supplier: ABBIOTEC
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
CHK2 (CHK2 checkpoint homolog) is a nuclear protein, a member of the CDS1 subfamily of serine/threonine protein kinases. CHK2 is a cell cycle checkpoint regulator and putative tumor suppressor. In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, it is known to inhibit CDC25C phosphatase,Porcinereventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also,Mouse,utations in this protein are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.
Catalogue number: 252785
Reactivities: Human
Applications: Immunofluorescence, Immunohistochemistry
Size: 0.1 ml
Accession: O96017
Antigen: Purified recombinant fragment of human CHK2 (aa481-531) e, Xenopus/Amphibian,pressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type: Mouse Monoclonal Antibody
Isotype: Mouse IgG2b
Clonality: 1C12B8
Additional info: Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2; CDS1; CHK2; RAD53; CHEK2;
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave