Home  >  Products  >  Chk2, phosphorylated (Thr68) (Checkpoint Kinase 2, Chek 2, Chek2, Chk 2, CDS 1, CDS1, HuCds 1, HuCds1, LFS2, PP1425, RAD 53, RAD53, Serine/threonine Protein Kinase Chk2)
Chk2, phosphorylated (Thr68) (Checkpoint Kinase 2, Chek 2, Chek2, Chk 2, CDS 1, CDS1, HuCds 1, HuCds1, LFS2, PP1425, RAD 53, RAD53, Serine/threonine Protein Kinase Chk2)

Chk2, phosphorylated (Thr68) (Checkpoint Kinase 2, Chek 2, Chek2, Chk 2, CDS 1, CDS1, HuCds 1, HuCds1, LFS2, PP1425, RAD 53, RAD53, Serine/threonine Protein Kinase Chk2)

Cat no: C4201-06P

Supplier: United States Biological
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Activated Chk2 phosphorylates and inhibits Cdc25C phosphatase, preventing the entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familial cancer usually associated with inherited mutations in TP53. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:10000-1:50000 Western Blot: 1:200-1:2000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C4201-06P
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Checkpoint-like protein CHK2, CHK2 Checkpoint Homolog (S. pombe), RP11-436C9.1
References: 1. Bartek, J. and Lukas, J. (2003) Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell. 3: 421-429. 2. Ahn, J. et al. (2004) The Chk2 protein kinase. DNA Repair (Amst). 3: 1039-1047.
Additional info: Recognizes human Checkpoint kinase 2 phosphorylated at Thr68.. Species sequence homology: mouse, chimpanzee and rat.

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