Chloroquine

Chloroquine is a prototypical anti-malarial drug, most widely used to treat all types of malarial infections. It is also the cheapest, time-tested and safe anti-malarial agent. Chloroquine is a hapten of molecular weight 158.29g/mol.\nThe quinoline moiety of the chloroquine molecule is the same as for many other antimalarial drugs, but the sidechain is unique.\n\nApplications: \nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

C5030

Size

100ul

Applications

ELISA

Hosts

Mouse

Form

Supplied as a liquid in PBS, pH 7.2, 15mM sodium azide.\n

P Type

Mab

Purity

Purified by Protein A/G affinity chromatography from culture supernatant.

Isotype

IgG2a,k

References

1. Rowell V, Rowell FJ, Baker A, Laurie D, Sidki AM (1988) A specific ELISA method for determining chloroquine in urine or dried blood spots. Bull World Health Organ 66:211-217.\n2. Shenton FC, Bots M, Menon A, Eggelte TA, de Wit M, Greenwood BM (1988) An ELISA test for detecting chloroquine in urine. Trans R Soc Trop Med Hyg 82:216-220.\n3. Escande C, Chevalier P, Verdier F, Bourdon R (1990) Sensitive radioimmunoassay and enzyme-linked immunosorbent assay for the simultaneous determination of chloroquine and its metabolites in biological fluids. J Pharm Sci 79:23-27.

Additional Info

Has specificity for chloroquine and can be used for chloroquine quantification in human serum or plasma with a detection limit of approximately 20ng/ml.\nEpitope: has specificity for the non-quinoline-sidechain of chloroquine.\nAble to distinguish chloroquine from the metabolite desethylchloroquine and exhibits no crossreactivity to other antimalarial drugs.