Chlorothricin (Antibiotic K 818A)

Cat no: C5032-05

Supplier: United States Biological

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The tetronic acid, chlorothricin is an unusual macrocyclic antibiotic from a Streptomyces sp.. It shows inhibitory activity against cholesterol biosynthesis from mevalonate and inhibits pyruvate carboxylases purified from rat liver, chicken liver and Azotobacter vinelandii. Solubility: Soluble in ethyl acetate, ethanol, methanol, DMF or DMSO. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with ethyl acetate, ethanol, methanol, DMF or DMSO..Aliquot and store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Catalogue number:	C5032-05
Size:	1mg
Form:	Supplied as a white powder.
Purity:	~ 99% by HPLC
Alternative names:	Antibiotic K 818A
References:	1. New cholesterol biosynthesis inhibitors MC-031 (O-demethylchlorothricin), -032 (O-demethyl hydroxy-chlorothricin), -033 and -034. Kawashima A. et al.,J. Antibiot. 1992, 45, 207. 2. Mode of action of the macrolide-type antibiotic, chlorothricin. Effect of the antibiotic on the catalytic activity and some structural parameters of pyruvate carboxylases purified from rat and chicken liver. Schindler P.W. et al. Eur. J. Biochem. 1975, 55, 543.

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Chlorothricin (Antibiotic K 818A)

Cat no: C5032-05

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