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Cholecystokinin B Receptor (CCKB Receptor, CCKBR, Gastrin Receptor, GASR, HGNC:1571)

Cholecystokinin B Receptor (CCKB Receptor, CCKBR, Gastrin Receptor, GASR, HGNC:1571)

Cat no: C5042-25B

Supplier: United States Biological
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This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 1ug/ml. Detects bands at 55kD and 26kD in human pancreas lysates Immunohistochemistry (Paraffin): 3ug/ml. Human pancreas shows strong staining in Islets of Langerhans and weak staining in acinar cells. Also suitable for use in frozen sections. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol 40-50%, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C5042-25B
Reactivities: Human
Hosts: Goat
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris-saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Olszewska-Pazdrak B, Townsend CM Jr, Hellmich MR. Agonist-independent activation of Src tyrosine kinase by a cholecystokinin-2 (CCK2) receptor splice variant. J Biol Chem. 2004 Sep 24;279(39):40400-4. Epub 2004 Jul 29. PMID: 15292208
Additional info: Recognizes human Cholecystokinin B Receptor (CCKB Receptor, CCKBR, Gastrin Receptor, GASR, HGNC:1571). Species sequence homology: mouse

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