Cholinergic Receptor, Nicotinic, alpha 5 (CHRNA5)

Cat no: C5062-74B

Supplier: United States Biological

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Description
Additional Information

Nicotinic acetylcholine receptors, also known as nAChRs, belong to a family of proteins called ligand gated ion channels and are widely expressed throughout the nervous system. nAChRs are made up of 5 subunits (two alpha and three beta). Nicotinic Acetylcholine Receptor a5 has an ax ay beta combination. In the CNS, the a5 subunit is widely expressed in the CA1 area of the hippocampus which affects learning, memory, attention, anxiety, and potentially drug seeking behaviors. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500 Optimal dilutions to be determined by the researcher. Positive Control: Rat e16 brain lysate Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Catalogue number:	C5062-74B
Reactivities:	Rat
Hosts:	Rabbit
Applications:	Western Blot
Size:	100ug
Form:	Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
P type:	Pab
Purity:	Purified by immunoaffinity chromatography.
References:	1. Salas, R., et al. (2003). Mol Pharmacol. 63:1059
Additional info:	Recognizes rat Nicotinic Acetylcholine Receptor a5.

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Cholinergic Receptor, Nicotinic, alpha 5 (CHRNA5)

Cat no: C5062-74B

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