Home  >  Products  >  Cholinergic Receptor, Nicotinic, alpha 7, Exons 5-10 (CHRFAM7A, CHRNA7 and FAM7A Family with Sequence Similarity 7A, Exons A-E Fusion, CHRNA7, CHRNA7-DR1, CHRNA7-FAM7A Fusion Protein, D-10, MGC120482, MGC120483)
Cholinergic Receptor, Nicotinic, alpha 7, Exons 5-10 (CHRFAM7A, CHRNA7 and FAM7A Family with Sequence Similarity 7A, Exons A-E Fusion, CHRNA7, CHRNA7-DR1, CHRNA7-FAM7A Fusion Protein, D-10, MGC120482, MGC120483)

Cholinergic Receptor, Nicotinic, alpha 7, Exons 5-10 (CHRFAM7A, CHRNA7 and FAM7A Family with Sequence Similarity 7A, Exons A-E Fusion, CHRNA7, CHRNA7-DR1, CHRNA7-FAM7A Fusion Protein, D-10, MGC120482, MGC120483)

Cat no: C5062-74

Supplier: United States Biological
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The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA:1:1000 Optimal dilutions to be determined by the researcher. Positive Control: Human Brain (Amygdala, Hippocampus, Cerebellum) lysates Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 monthsat -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Peptide Blocking: Corresponding peptide is available for Peptide Blocking studies. See C5062-74-P. Antibody
Catalogue number: C5062-74
Reactivities: Human
Hosts: Goat
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: Martin LF, Leonard S, Hall MH, Tregellas JR, Freedman R, Olincy A. Sensory gating and alpha-7 nicotinic receptor gene allelic variants in schizoaffective disorder, bipolar type. Am J Med Genet B Neuropsychiatr Genet. 2007 Jul 5;144(5):611-4. PMID: 17192894
Additional info: Recognizes human CHRFAM7A.

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