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Cholinergic Receptor, Nicotinic, beta 2 (CHRNB2, EFNL3, nAChRB2, cholinergic receptor, nicotinic, beta Polypeptide 2 (neuronal), neuronal nicotinic acetylcholine receptor beta 2)

Cholinergic Receptor, Nicotinic, beta 2 (CHRNB2, EFNL3, nAChRB2, cholinergic receptor, nicotinic, beta Polypeptide 2 (neuronal), neuronal nicotinic acetylcholine receptor beta 2)

Cat no: C5062-75A

Supplier: United States Biological
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Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:64000 Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human Brain (Cerebellum, Cerebral Cortex) lysates Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C5062-75A
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris, pH 7.2, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Purity: Purified by affinity chromatography.
References: 1. Cook LJ, Ho LW, Taylor AE, Brayne C, Evans JG, Xuereb J, Cairns NJ, Pritchard A, Lemmon H, Mann D, St Clair D, Turic D, Hollingworth P, Moore PJ, Jehu L, Archer N, Walter S, Foy C, Edmondson A, Powell J, Lovestone S, Owen MJ, Williams J, Lendon C, Rubinsztein DC. Candidate gene association studies of the alpha 4 (CHRNA4) and beta 2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease. Neurosci Lett. 2004 Mar 25;358(2):142-6. PMID: 15026168
Additional info: Recognizes human CHRNB2 at ~48kD.

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