Chrysomycin B (Chrysomycin M, Virenomycin M, Albacarcin M)

Cat no: C5071-30A

Supplier: United States Biological

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Chrysomycin B is a minor analogue in a complex of C-glycoside antitumor actives isolated from Streptomyces. Chrysomycin B, containing a methyl group in the 8-position, is less active than its vinyl analogue (Chrysomycin A), albeit still a potent antitumor active and an inhibitor of the catalytic activity of human topoisomerase II. More recent research on related metabolites, the gilvocarcins, suggests that chrysomycins may act as photoactivated crosslinkers of DNA to histones. Purity: >98% by HPLC Solubility: Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Related to: Chrysomycin A, Gilvocarcin M, Gilvocarcin V, O-Deacetyl-ravidomycin

Catalogue number:	C5071-30A
Size:	500ug
Purity:	>98% by HPLC
Alternative names:	Chrysomycin M, Virenomycin M, Albacarcin M
References:	1. Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated gilvocarcin V in human fibroblasts. Matsumoto A. et al. Cancer Res. 2000, 60, 3921. 2. Chrysomycin derivative compounds and use as antitumor agents. US Patent 6,030,951, 2000. 3. Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II. Lorico A. et al. Eur. J. Cancer 1993, 29A, 1985.

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Chrysomycin B (Chrysomycin M, Virenomycin M, Albacarcin M)

Cat no: C5071-30A

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