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CIDE-A, CT (Cell Death Activator CIDE-A, Cell Death-inducing DFFA-like Effector A, CIDEA)

CIDE-A, CT (Cell Death Activator CIDE-A, Cell Death-inducing DFFA-like Effector A, CIDEA)

Cat no: C5072-01D

Supplier: United States Biological
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Apoptosis is related to many diseases and induced by a family of cell death receptors. Cell death signals are transduced by DD-, DED-, or CARD-containing molecules and members of the caspase family of proteases. These death signals cause the final degradation of chromosomal DNA by activated DNase DFF40/CAD, which is chaperoned and inhibited by DFF45/ICAD. DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE-A induces DNA fragmentation and activates apoptosis, which is inhibited by DFF45. CIDE-A is expressed in many tissues. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.25-0.5ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human brain tissue lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C5072-01D
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Liu, X. et al. Cell 89,175-184 (1997). 2. Enari, M. et al. Nature 391,43 (1998). 3. Sakahira, H. et al. Nature 391,96 (1998). 4. Liu, X. et al. Proc. Natl. Acad. Sci. USA; 95,8461 (1998). 5. Inohara ,N. et al. EMBO J.17, 2526 (1998). 6. Lugovskoy, AA. et al. Cell 99, 747 (1999).
Additional info: Recognizes human CIDE-A.

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