Charge heterogeneity is a key attribute of biomolecules such as antibody, enzyme, and protein, affecting the molecule's stability, solubility, and biological activity. Changes of deamidation, oxidation, glycosylation, glycation, the N- or C-terminal, loss of three-dimensional structure, or reduction of disulfide bonds may lead to changes in charge heterogeneity. Since charge heterogeneity directly or indirectly affects the efficacy and safety of biomolecules, the analysis of charge heterogeneity occup......
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