CIITA (T740) pAb

Cat no: BS2471

Supplier: Bioworld Technology, Inc.

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Description
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The transactivator CIITA regulates basal and interferon-induced expression of MHC class II genes. CIITA restores expression of all MHC II gene expression in mutant cells and corrects regulatory defects of those genes. Activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. CIITA may act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter.

Catalogue number:	BS2471
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Western Blot
Size:	100ug/100ul
Swiss prot:	P33076
Dilutions:	WB: 1:500~1:1000
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to amino acids 720-760 of Human CIITA.
Species:	CIITA (T740) pAb detects endogenous levels of CIITA protein.
Molecular weight:	~ 97, 123 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	MHC class II transactivator; CIITA; C2TA; MHC2TA
Additional info:	For research use only, not for use in diagnostic procedure.

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CIITA (T740) pAb

Cat no: BS2471

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