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CITED 2 (Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2, MRG1, P35SRJ)

CITED 2 (Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2, MRG1, P35SRJ)

Cat no: C5675-06A

Supplier: United States Biological
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Cited 2 is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a proposed negative regulator for hypoxia-inducible factor-1 alpha. Recruitment of CBP/p300 by HIF-1 is essential for the transcriptional response to hypoxia. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500 detects a band at 29kD. Additional bands may be seen at 36kD (p35srj) and 70kD (unknown) Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C5675-06A
Reactivities: Human
Hosts: Mouse
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid, 0.1% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Ascites
Alternative names: Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2, MRG1, P35SRJ
References: 1. Leung, M-K., et al. Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1. Genomics. 61: 307-313, 1999. 2. Yin, Z., et al. The essential role of Cited 2, a negative regulator for HIF-1 alpha, in heart development and neurulation. PNAS. 99(16): 10488-10493, 2002. 3.Tien E et al., J Biol chem Jun 4l; 279 (23) 24053-63 (2004) 4. Banforth S et.a;, Nat Genet Nov 36 (11): 1189-96 (2004) 5. Bhattacharya S et.al., Genes Dev Jan1;13(1)64-75 (1999) 6. Haase M. et al, J Endocrinol Feb; 192(2):459-65 (2007)
Additional info: Recognizes human CITED 2. Species Crossreactivity: Does not work well on mouse.

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