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CLARA CELL PROTEIN (CC10, CC16, CCPBP, CCSP, Clara cell phospholipid-binding protein, Clara cells 10kD secretory protein, Secretoglobin family 1A member 1, UGB, UP1, Urinary protein 1, Urine Protein 1, Uteroglobin Precursor)

Cat no: C5828-01B

CLARA CELL PROTEIN (CC10, CC16, CCPBP, CCSP, Clara cell phospholipid-binding protein, Clara cells 10kD secretory protein, Secretoglobin family 1A member 1, UGB, UP1, Urinary protein 1, Urine Protein 1, Uteroglobin Precursor)

Clara cell protein or urinary protein 1 is a homodimeric protein of 16kD and is secreted predominantly by Clara cells in terminal bronchioles and from puberty on in the male urogenital tract. CC16 is formed by two chains, each with a molecular weight of 7.9kD. CC16 occurs in very high concentrations in respiratory tract derived fluids such as sputum or bronchoalveolar lavage fluid. CC16 occurs also in urogenital secretions, such as amniotic fluid, urine and semen. The protein difusses passively into serum. CC16 behaves like an anti-cytokine by downregulating the production of IFN-gamma, IL-1 and TNF-alpha by stimulated leukocytes. Besides this, CC16 reduces the antiviral activity and the augmentation of phagocytosis induced by IFN-gamma.\n\nApplications: \nSuitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilutions:\nWestern Blot: 1:50\nImmunohistochemistry (frozen/paraffin): 1:50\nOptimal dilution to be determined by researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C5828-01B

Size

100ug

Applications

IHC, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1

References

1. Geerts, L et al; Natural inhibitors of neutrophil function in acute respiratory distress syndrome. Crit Care Med 2001, 29: 1920

Additional Info

Recognizes the anti-inflammatory mediator Clara cell protein (CC16).

Alternative Names

Clara cell protein

Read more on Supplier website

SUPPLIER INFO

Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info

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