Home  >  Products  >  CLARA CELL PROTEIN (CC10, CC16, CCPBP, CCSP, Clara cell phospholipid-binding protein, Clara cells 10kD secretory protein, Secretoglobin family 1A member 1, UGB, UP1, Urinary protein 1, Urine Protein 1, Uteroglobin Precursor)
CLARA CELL PROTEIN (CC10, CC16, CCPBP, CCSP, Clara cell phospholipid-binding protein, Clara cells 10kD secretory protein, Secretoglobin family 1A member 1, UGB, UP1, Urinary protein 1, Urine Protein 1, Uteroglobin Precursor)

CLARA CELL PROTEIN (CC10, CC16, CCPBP, CCSP, Clara cell phospholipid-binding protein, Clara cells 10kD secretory protein, Secretoglobin family 1A member 1, UGB, UP1, Urinary protein 1, Urine Protein 1, Uteroglobin Precursor)

Cat no: C5828-01B

Supplier: United States Biological
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Clara cell protein or urinary protein 1 is a homodimeric protein of 16kD and is secreted predominantly by Clara cells in terminal bronchioles and from puberty on in the male urogenital tract. CC16 is formed by two chains, each with a molecular weight of 7.9kD. CC16 occurs in very high concentrations in respiratory tract derived fluids such as sputum or bronchoalveolar lavage fluid. CC16 occurs also in urogenital secretions, such as amniotic fluid, urine and semen. The protein difusses passively into serum. CC16 behaves like an anti-cytokine by downregulating the production of IFN-gamma, IL-1 and TNF-alpha by stimulated leukocytes. Besides this, CC16 reduces the antiviral activity and the augmentation of phagocytosis induced by IFN-gamma. Applications: Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1:50 Immunohistochemistry (frozen/paraffin): 1:50 Optimal dilution to be determined by researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C5828-01B
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
Alternative names: Clara cell protein
References: 1. Geerts, L et al; Natural inhibitors of neutrophil function in acute respiratory distress syndrome. Crit Care Med 2001, 29: 1920
Additional info: Recognizes the anti-inflammatory mediator Clara cell protein (CC16).

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