Clara Cell Protein (CC16, CC10, Uteroglobin, Urinary Protein 1, Clara Cell Secretory Protein, Secretoglobin Family 1A Member 1, CCPBP, Clara Cells 10kD Secretory Protein, CC10, UP1, Clara Cell Phospholipid-binding Protein, SCGB1A1, CCSP, UGB)

This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. \n\nClara cells are dome-shaped cells with short microvilli found in the small airways (bronchioles) of the lungs.[1] Clara cells are found in the ciliated simple epithelium. These cells may secrete glycosaminoglycans to protect the bronchiole lining. Bronchiolar cells gradually increase in number as the number of goblet cells decrease. They are also known as "bronchiolar exocrine cells".[2] One of the main functions of Clara cells is to protect the bronchiolar epithelium. They do this by secreting a small variety of products, including Clara cell secretory protein (CCSP) and a solution similar to the component of the lung surfactant. They are also responsible for detoxifying harmful substances inhaled into the lungs. Clara cells accomplish this with cytochrome P450 enzymes found in their smooth endoplasmic reticulum. Clara cells also act as a stem cell and multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium.[5]\n[edit]Mechanism\n\nThe respiratory bronchioles represent the transition from the conducting portion to the respiratory portion of the respiratory system. The narrow channels are usually less than 2 mm in diameter and they are lined by a simple cuboidal epithelium, consisting of ciliated cells and non-ciliated Clara cells, which are unique to bronchioles. In addition to being structurally diverse, Clara cells are also functionally variable. One major function they carry out is the synthesis and secretion of the material lining the bronchiolar lumen. This material includes glycosaminoglycans, proteins such as lysozymes, and conjugation of the secretory portion of IgA antibodies. These play an important defensive role, and they also contribute to the degradation of the mucus produced by the upper airways. The heterogeneous nature of the dense granules within the Clara cell's cytoplasm suggests that they may not all have a secretory function. Some of them may contain lysosomal enzymes, which carry out a digestive role, either in defense: Clara cells engulf airborne toxins and break them down via their cytochrome P-450 enzymes (particularly CYP4B1, which is only present in the clara cells) present in their smooth endoplasmic reticulum; or in the recycling of secretory products. Clara cells are mitotically active cells. They divide and differentiate to form both ciliated and non-ciliated epithelial cells.\n\nClara cells contain Tryptase clara, which is believed to be responsible for cleaving the hemagglutinin surface protein of influenza A virus, thereby activating it and causing the symptoms of flu.[6] When the l7Rn6 protein is disrupted in mice, these mice display severe emphysema at birth as a result of disorganization of the Golgi apparatus and formation of aberrant vesicular structures within clara cells.[7]\n\nApplications:\nWestern Blot: 1:500-1:2000\nFlow Cytometry: 1:200-1:400\nELISA: 1:10000\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

030105

Size

100ug

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

Form

Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer

P Type

Mab

Purity

Purified

Isotype

IgG1

References

1.Transplantation. 2010 Aug 15;90(3):340-2. 2.Neonatology. 2010;97(3):228-34.\nGeneral References:\n1. Atkinson JJ, Adair-Kirk TL, Kelley DG, Demello D, Senior RM (2008). \"Clara cell adhesion and migration to extracellular matrix\". Respir. Res. 9 (1): 1. doi:10.1186/1465-9921-9-1. PMC 2249579. PMID 18179694.\n2. Peter J. Papadakos; Burkhard Lachmann (29 August 2007). Mechanical Ventilation: Clinical Applications and Pathophysiology. Elsevier Health Sciences. pp. 74

Additional Info

Human