Home  >  Products  >  Claudin 3 (Claudin-3, CLDN3, C7orf1, Clostridium perfringens Enterotoxin Receptor 2, CPE-receptor 2, CPETR2, CPE-R 2, CPE-R2, CPETR2, Rat Ventral Prostate.1 Protein Homolog, RVP1, hRVP1)
Claudin 3 (Claudin-3, CLDN3, C7orf1, Clostridium perfringens Enterotoxin Receptor 2, CPE-receptor 2, CPETR2, CPE-R 2, CPE-R2, CPETR2, Rat Ventral Prostate.1 Protein Homolog, RVP1, hRVP1)

Claudin 3 (Claudin-3, CLDN3, C7orf1, Clostridium perfringens Enterotoxin Receptor 2, CPE-receptor 2, CPETR2, CPE-R 2, CPE-R2, CPETR2, Rat Ventral Prostate.1 Protein Homolog, RVP1, hRVP1)

Cat no: C5838-25C

Supplier: United States Biological
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Claudins are integral membrane proteins involved in the assembly and function of tight junction strands. Claudins have 4 transmembrane domains and 2 extracellular loops and C-terminal tail containing PDZ-binding motifs and YV sequences. Claudin 3, a human homolog of rat RVP1, is a unique member of this family. It is a low-affinity receptor for Clostridium perfringes entertoxin capable of mediating toxin-dependent cytolysis. Claudin-3 has been found to be phosphorylated and up-regulated in various cancer types suggesting a potential role in tumorigenesis. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 1:50-1:100 Optimal dilutions to be determined by the researcher. Positive Control: Small intestine Cellular Localization: Cytoplasmic and cell membrane Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C5838-25C
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid in 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Turksen et.al J Cell Sci 117; 2435-2447 (2004). 2. Agarwal et.al Cancer Res 65; 7378-7385 (August 15, 2005).
Additional info: Recognizes human Claudin 3. Species Crossreactivity: rat and mouse.

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