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CLC4, CT (H(+)/Cl(-) Exchange Transporter 4, Chloride Channel Protein 4, Chloride Transporter ClC-4, ClC-4, CLCN4) (APC)

Cat no: C5837-20A-APC

CLC4, CT (H(+)/Cl(-) Exchange Transporter 4, Chloride Channel Protein 4, Chloride Transporter ClC-4, ClC-4, CLCN4) (APC)

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders.\n\nApplications: \nSuitable for use in ELISA, Western Blot, and Immunofluorescence. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-1:500\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C5837-20A-APC

Size

200ul

Applications

ELISA, IF, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Allophycocyanin (APC).

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

1.Wang, T., et al., Gastroenterology 126(4):1157-1166 (2004). 2.Lamb, F.S., et al., J. Mol. Cell. Cardiol. 31(3):657-666 (1999). 3.Dinulos, M.B., et al., Genomics 35(1):244-247 (1996). 4.Schnur, R.E., et al., Hum. Genet. 95(5):594-595 (1995). 5.van Slegtenhorst, M.A., et al., Hum. Mol. Genet. 3(4):547-552 (1994).

Additional Info

Recognizes human CLC4.

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