Home  >  Products  >  CLCF1, Recombinant, Human, aa28-225, His-tag (Cardiotrophin-like Cytokine Factor 1, B-cell-stimulating Factor 3, BSF-3, Novel Neurotrophin-1, NNT-1, BSF3, CLC, NNT1)

CLCF1, Recombinant, Human, aa28-225, His-tag (Cardiotrophin-like Cytokine Factor 1, B-cell-stimulating Factor 3, BSF-3, Novel Neurotrophin-1, NNT-1, BSF3, CLC, NNT1)

Cat no: 029649


Supplier: United States Biological
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CLCF1, belongs to the interleukin 6 family of cytokines, which are involved in cell signaling through phosphorylation of gp130. CLCF1 has a sequence of 225aa with a 27aa signal peptide, a molecular mass of 22kD in mature form, and the highest homology to cardiotrophin-1 and ciliary neurotrophic factor. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Source: Recombinant corresponding to aa28-225 from human CLCF1, fused to His-tag, expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF Molecular Weight: ~24.6kD Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: 029649
Size: 100ug
Form: Supplied as a liquid in 20mM sodium citrate, pH 3.5, 0.4M urea, 10% glycerol.
Purity: ~90% (SDS-PAGE)
References: 1. Senaldi G., et al. (1999) Proc. Natl. Acad. Sci. U.S.A. 96:11458-11463. 2. Shi Y., et al. (1999) Biochem. Biophys. Res. Commun. 262:132-138.

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