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Cleaved-ADAM17 (R215) pAb

Cleaved-ADAM17 (R215) pAb

Cat no: BS7064

Supplier: Bioworld Technology, Inc.
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Tumor necrosis factor (beta) (TNF(beta)), also known as lymphotoxin, is a pleiotropic cytokine. TNF(alpha), also known as cachetin, is a cytokine that binds to the same receptors, producing an array of effects similar to those of TNF(beta). TNF(beta) and TNF(alpha) share 30% amino acid homology and have similar biological activities. TNF(beta) is produced by activated lymphocytes, including CD4+ T helper cell type 1 lymphocytes, CD8+ lymphocytes and certain B lymphoblastoid cell lines. TNF(alpha) is produced by several different cell types, including lymphocytes, neutrophils and macrophages. TNF(beta) and TNF(alpha) can modulate many immune and inflammatory functions while having the ability to inhibit tumor growth. TACE (for TNF(alpha) converting enzyme) is a metalloproteinase that cleaves the membrane-bound TNF(alpha) precursor to release soluble TNF(alpha).
Catalogue number: BS7064
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: P78536
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 180-230 of Human Cleaved-ADAM17.
Species: Cleaved-ADAM17 (R215) pAb detects endogenous levels of Cleaved-ADAM17 (67 kDa) protein.
Molecular weight: ~ 67, 93 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD156b; ADAM17; CSVP; TACE
Additional info: For research use only, not for use in diagnostic procedure.

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