Cleaved-ADAM17 (R215) Peptide

Tumor necrosis factor beta (TNFbeta), also known as lymphotoxin, is a pleiotropic cytokine. TNFalpha, also known as cachetin, is a cytokine that binds to the same receptors, producing an array of effects similar to those of TNFbeta. TNFbeta and TNFalpha share 30% amino acid homology and have similar biological activities. TNFbeta is produced by activated lymphocytes, including CD4+ T helper cell type 1 lymphocytes, CD8+ lymphocytes and certain B lymphoblastoid cell lines. TNFalpha is produced by several different cell types, including lymphocytes, neutrophils and macrophages. TNFbeta and TNFalpha can modulate many immune and inflammatory functions while having the ability to inhibit tumor growth. TACE (for TNFalpha converting enzyme) is a metalloproteinase that cleaves the membrane-bound TNFalpha precursor to release soluble TNFalpha.

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SPECIFICATIONS

Catalog Number

BS7064P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide Cleaved-ADAM17 (R215). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P78536

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS7064 Cleaved-ADAM17 (R215) pAb.

Alternative Names

Disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD156b; ADAM17; CSVP; TACE