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Cleaved-Caspase-3 p17 (D175) Polyclonal Antibody

Cleaved-Caspase-3 p17 (D175) Polyclonal Antibody

Cat no: ABP50003

Supplier: Abbkine Scientific Co.Ltd.
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CASP3 encodes caspase 3 which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspase 3 cleaves and activates caspases 6, 7 and 9, and caspase 3 itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of CASP3 results in two transcript variants that encode the same protein.
Catalogue number: ABP50003
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Immunofluorescence, Immunohistochemistry - fixed, Western Blot
Size: 30micro l, 100micro l, 200micro l
Accession: P42574
Gene: 836
Concentration: 1 mg/ml
Isotype: Rabbit IgG
Clonality: Polyclonal

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